What is it used for?
Zofran Injection is used to help stop the nausea (sick feeling) and vomiting which can occur after medical treatments and operations.

Contraindications and cautions:
You must not take Zofran Injection if:
* you have ever had an allergic reaction to ondansetron or any of the ingredients listed toward the end of this leaflet. (See "Ingredients")
* you are pregnant, trying to become pregnant or breast feeding, unless your doctor says it is safe.
* the expiry date (EXP) printed on the pack has passed.
* the packaging is torn or shows signs of tampering
* the injection solution is coloured, cloudy or lumpy
You must tell your doctor if:
* you are allergic to foods, dyes, preservatives or any other medicines.
* you have had to stop taking another medicine for your nausea or vomiting.
* you are taking any other medicines, including medicines you buy without a prescription.
* you have or used to have liver problems.
* you are breastfeeding, pregnant or trying to become pregnant.

Side effects:
Like all medicines, Zofran Tablets may cause some side effects. Tell your doctor if you notice any of the following side effects and they worry you:
• headache
• a sensation of warmth or flushing
• constipation
• hiccups
These are all mild side effects.
Tell your doctor immediately or go to your casualty at your nearest hospital if you notice any of the following side effects:
• 'wheezy' symptoms
• chest pain or tightness of chest
• changes in the way your heart beats eg if you notice it beating faster or slower than normal, or if it beats irregularly or if it 'throbs'
• low blood pressure
• fits or convulsions
• swelling of the eyelids, face, lips, mouth or throat which may cause difficulty in swallowing or breathing
• skin rash, skin lumps or hives
• problems with muscles or movement.
These are all serious side effects. Serious side effects are rare.

Interactions:
Tell your doctor the names of any medicines you are taking, including those you buy without a prescription from a pharmacy, supermarket or health food shop.
In particular, tell your doctor if you are taking:
• Carbamazepine (Tegretol™, Teril™) - a medicine for epilepsy, bipolar disorder and some pain conditions
• Rifampicin (Rifadin™, Rifanah™) - an antibiotic used for tuberculosis and other infections
• Phenytoin (Dilantin™) - a medicine for epilepsy
• Tramadol (Tramal™, Zytram™) - a medicine for pain
Some medicines may affect the way other medicines work