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Brand Name: Cefazolin
Manufactured: Hoffmann-La Roche
Active Ingradients: Cefazolin sodium
Therapeutic actions: Cefazolin belongs to a group of antibiotics called cephalosporin's. It works by killing the bacteria that are causing an infection.
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What is it used for?
• Respiratory Tract Infections:
Due to S. pneumoniae, S. aureus (including β-lactamase-producing strains), and S. pyogenes.
• Urinary Tract Infections:
Due to E. coli, P. mirabilis.
• Skin and Skin Structure Infections:
Due to S. aureus (including β-lactamase-producing strains), S. pyogenes, and other strains of streptococci.
• Biliary Tract Infections:
Due to E. coli, various strains of streptococci, P. mirabilis, and S. aureus.
• Bone and Joint Infections:
Due to S. aureus.
• Genital Infections:
(i.e., prostatitis, epididymitis) due to E. coli, P. mirabilis.
• Septicemia:
Due to S. pneumoniae, S. aureus (includingβ-lactamase-producing strains) P. mirabilis, E. coli.
• Endocarditis:
Due to S. aureus (including β-lactamase-producing strains), and S. pyogenes.
• Perioperative Prophylaxis:
The prophylactic administration of Cefazolin preoperatively, intraoperatively, and postoperatively may reduce the incidence of certain postoperative infections in patients undergoing surgical procedures which are classified as contaminated or potentially contaminated.
Contraindications and cautions: Prolonged use of Cefazolin may result in the overgrowth of non susceptible organisms. Patients should be counseled that antibacterial drugs including Cefazolin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold).
Do not use m-Cefazolin if you have had a serious allergic reaction to any other cephalosporin antibiotic or penicillin antibiotic.
Cephalosporins may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated.
This drug should be used during pregnancy only if clearly needed.
Side effects:
Tell your doctor or health care professional as soon as possible if you do not feel well while you are receiving Cefazolin. Like other medicines, Cefazolin may cause some unwanted side effects. Sometimes they are serious, most of the time they are not.
Tell your doctor if you notice any following effects:
• pain, swelling or red skin where you had the injection
• diarrhea
• severe chills, sore throat or mouth ulcers
• skin problems such as rash or itchiness
• bleeding or bruising more easily than normal
• signs of anaemia, such as tiredness, being short of breath and looking pale
• yellowing of the skin and eyes, also called jaundice
• swelling of the face, lips, mouth or throat which may cause difficulty in swallowing or breathing
Interactions: Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.
A false positive reaction for glucose in the urine may occur with Benedict’s solution, Fehling’s solution or with CLINITEST tablets, but not with enzyme-based tests such as CLINISTIX.
Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery.
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