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Coumadin (Warfarin sodium) is an anticoagulant agent that decreases the amount of blood clotting proteins in the body. It comes as oral tablets and is used for treating and prevention of thrombosis, thromboembolism and atrial fibrillation. The drug also helps to treat recurrent myocardial infarctions and prevent further cardiovascular accidents.
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What is Coumadin?
Coumadin is an anticoagulant medication licensed to treat and prevent the formation of blood clots due to various causes. It comes as oral tablets with various strengths of Warfarin sodium as active ingredient. The agent works by stopping the formation of active forms of some blood-clotting substances. However, it doesn’t dissolve blood clots, but rather keeps their formation in check, allowing them to dissolve naturally. It also prevents blood clots migration elsewhere in the body, reducing the risk of heart attack, stroke and other serious conditions.

When is Coumadin indicated?
Coumadin is indicated for the treatment and prophylaxis of venous thrombosis, pulmonary embolism and thromboembolic complications due to atrial fibrillation, artificial cardiac valve or certain surgeries, including hip or knee replacement. It is also prescribed to lower the risk of death, recurrent heart attacks and thromboembolic events, such as systemic embolization and stroke after a heart attack.

How to take Coumadin?
Coumadin should be taken by mouth, without regard to food, typically once daily. The medication is difficult to dose as it differs from other drugs. The dosage must be individualized in accordance with the prothrombin time or INR blood test. Monitoring should be done daily when first administering the drug until a stable and appropriate INR is reached. Thereafter monitoring should be performed periodically. Some patients may be prescribed to take their dose on certain days of the week or in different amounts on other days.

When is Coumadin contraindicated?
Coumadin is contraindicated in pregnant women, with the exception of women with artificial heart valves at risk of thromboembolism when the benefit clearly outweighs the risk. It shouldn’t be given to patients with bleeding tendencies or blood dyscrasia, recent or contemplated surgery or dental procedure, malignant hypertension or hypersensitivity to Warfarin.

What are Coumadin side effects?
Coumadin can provoke nausea, dizziness, stomach pain, diarrhea, general weakness and hair loss. These symptoms are bothersome but generally not dangerous. The risk of severe side effects as hemorrhage, necrosis, osteoporosis, purple toe syndrome, livedo reticularis, vasculitis, rash, swelling and difficulty breathing can be decreased by careful INR monitoring.