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Depo-Medrol (Methylprednisolone acetate) is a synthetic glucocorticoid, derivative of progesterone. It is used for adrenal insufficiency treatment as well as treatment of certain inflammatory diseases and conditions that require suppression of the immune system. The drug should be received in accordance with the dosage regimen determined by the doctor.
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What is Depo-Medrol?
Depo-Medrol is a synthetic glucocorticoid drug derived from progesterone. Like other steroids it is mainly used for treating certain inflammatory conditions, but also has a wider range of effects, including metabolism changes and immune responses. The drug contains Methylprednisolone acetate as main ingredient and is available in oral tablets with various strengths. It acts by preventing the release of substances in the body which cause inflammation, at the same time decreasing the immune system’s response to these conditions and reducing such symptoms as pain, swelling and allergic reactions.

When is Depo-Medrol indicated?
Depo-Medrol is indicated for treating various inflammatory conditions, such as arthritis, psoriasis, ulcerative colitis, Crohn’s disease; allergic conditions, such as atopic dermatitis, allergic rhinitis, bronchial asthma; certain conditions of eyes, skin, lungs, kidney and intestines; autoimmune diseases as systemic lupus; cancer and other illnesses involving immune cells. It can be prescribed for vestibular neuritis and may be useful in preventing embryos from being rejected when in vitro fertilization procedure is performed.

How to take Depo-Medrol?
Depo-Medrol tablets are administered by mouth in a dose prescribed by the doctor. It is necessary to receive your dosage at one and the same time each day to maintain an even level of the drug in your blood and avoid overdosing. Gradual dose tapering is necessary when stopping the drug to prevent severe side effects that occur after the natural production of cortisol by adrenal glands has been ceased.

When is Depo-Medrol contraindicated?
Depo-Medrol is contraindicated at individual intolerance to any of its ingredients. It mustn’t be used in patients with systemic fungal or viral infections, as well as in people with impaired circulation or idiopathic thrombocytopenic purpura.

What are Depo-Medrol side effects?
Long-term Depo-Medrol use can cause hyperglycemia, infection, headache, vertigo, paresthesia, facial puffiness, acne, edema, weight gain, stomach ulceration, congestive cardiac insufficiency, hypertension, glaucoma, high eye pressure, osteoporosis and psychosis. These effects are most likely to manifest when the drug is used at high doses. Sometimes the drug can cause sleeplessness and down moods.