Januvia

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Januvia (Sitagliptin) is an antihyperglycemic drug for type 2 diabetes mellitus. Working by increasing insulin production and decreasing blood sugar levels, the drug reduces the incidence of cardiovascular accidents as well as blindness, kidney damage, nerve problems and ED. It comes as a once-daily tablet, which can be crushed or split if needed.
  • Expire Date: May 2021
  • Delivery Time: ~7 days

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What is Januvia?
Januvia is a blood glucose lowering drug used to treat people with type 2 diabetes. It is an orally active inhibitor of dipeptidyl peptidase enzyme, which works by increasing insulin production in response to meals and decreasing the amount of sugar produced in the liver. The drug can be used alone or together with other anti-hyperglycemic drugs, such as Metformin. It was approved in 2006 and is marked for having fewer side effects in controlling blood glucose levels.

When is Januvia indicated?
Januvia is indicated for the treatment of type 2 diabetes mellitus in adults as an adjunct to diet, exercise and possibly to other blood glucose lowering drugs or insulin. Controlling sugar levels helps to reduce the risk of heart attack and stroke and prevent blindness, kidney damage, nerve and sexual function problems. The drug is ineffective for treating type 1 diabetes and diabetic ketoacidosis. The drug hasn’t been studied for use in children and patients with a history of pancreatitis.

How to take Januvia?
Januvia comes as a once-daily tablet, which should be taken by mouth with or without food. Most patients are administered 100 mg q24h. However the dose can be lowered depending on renal function, concomitant conditions and personal response to treatment. Patients with moderate renal insufficiency are typically administered 50 mg q24h. Patients with severe renal insufficiency are given 25 mg q24h. When prescribed together with insulin, a lower dose of insulin is required to avoid hypoglycemia.

When is Januvia contraindicated?
Januvia is contraindicated in patients with a history of severe hypersensitivity reaction to its main ingredient Sitagliptin, such as angioedema or anaphylaxis. It shouldn’t be prescribed to patients with acute or active pancreatitis. Safety and efficacy of the drug usage in pregnant, nursing and pediatric (children under 12) patients has not been established.

What are Januvia side effects?
Januvia has few side effects. Still, sometimes it may provoke headache, upper respiratory tract infections and diarrhea. If these effects do occur they are usually minor. In rare cases the drug may cause low blood sugar, allergic reactions and abdominal pain. Get immediate medical help if you develop any signs of pancreatitis, such as loss of appetite, persistent nausea and vomiting or severe abdominal pain.