|
|
|
.
|
 |
Brand Name: Kenazole
Manufactured: Pharma Inernaitional
Active Ingredients: Ketoconazole
Therapeutic actions: Alters the permeability of the cell wall by blocking fungal cytochrome P450; inhibits biosynthesis of triglycerides and phospholipids by fungi; inhibits several fungal enzymes that results in a build-up of toxic concentrations of hydrogen peroxide;
|
|
|
|
|
| DRUGS |
FORM |
Q-TY |
PRICE |
ORDER |
|
| Kenazole 2% 100ml |
Shampoo |
1 |
17.20 $ |
|
| |
| |
What is it used for?
Treatment of susceptible fungal infections, including candidiasis, oral thrush, blastomycosis, histoplasmosis, paracoccidioidomycosis, coccidioidomycosis, chromomycosis, candiduria, chronic mucocutaneous candidiasis, as well as certain recalcitrant cutaneous dermatophytoses; used topically for treatment of tinea corporis, tinea cruris, tinea versicolor, and cutaneous candidiasis, seborrheic dermatitis.
Contraindications and cautions:
Hypersensitivity to ketoconazole or any component of the formulation; CNS fungal infections (due to poor CNS penetration); coadministration with ergot derivatives or cisapride is contraindicated due to risk of potentially fatal cardiac arrhythmias
Use with caution in patients with impaired hepatic function; has been associated with hepatotoxicity, including some fatalities; perform periodic liver function tests; high doses of ketoconazole may depress adrenocortical function.
Side effects:
Nausea/vomiting (3% to 10%), abdominal pain (1%)
Headache, dizziness, somnolence, fever, chills, bulging fontanelles, depression, gynecomastia, diarrhea, impotence, thrombocytopenia, leukopenia, hemolytic anemia, hepatotoxicity, photophobia
Cream: Severe irritation, pruritus, stinging (~5%)
Shampoo: Increases in normal hair loss, irritation (<1%), abnormal hair texture, scalp pustules, mild dryness of skin, itching, oiliness/dryness of hair
Interactions: Substrate of CYP3A4 (major); Inhibits CYP1A2 (strong), 2A6 (moderate), 2B6 (weak), 2C8/9 (strong), 2C19 (moderate), 2D6 (moderate), 3A4 (strong)
Benzodiazepines: Alprazolam, diazepam, temazepam, triazolam, and midazolam serum concentrations may be increased; consider a benzodiazepine not metabolized by CYP3A4 (such as lorazepam) or another antifungal that is metabolized by CYP3A4. Concurrent use is contraindicated.
|
.
|
|
