Sinequan

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Sinequan (Doxepin) is a tricyclic antidepressant licensed to treat mood disorders. It works by affecting certain brain chemicals, helping to improve depressive symptoms and reduce anxiety. It comes in capsules for oral use and is typically taken once daily before bedtime. Sometimes it can be administered on a divided dosing schedule, i.e. 2 or 3 times a day.
  • Expire Date: Oct 2020
  • Delivery Time: ~7 days

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What is Sinequan?
Sinequan is a tricyclic antidepressant medication licensed to treat certain affective disorders. It contains Doxepin hydrochloride as active ingredient, which is known to act by raising the levels of serotonin and norepinephrine, and allowing them to stay in the brain longer, thus helping to elevate mood. It also blocks the activity of histamine, dopamine and acetylcholine receptors. The drug comes in oral capsules with various strengths, and is usually taken before bedtime.

When is Sinequan indicated?
Sinequan is indicated for treating depression and anxiety in psychoneurotic patients, alcoholic patients as well as depression and anxiety associated with organic diseases. It is also prescribed for psychotic depressive symptoms with associated anxiety, including manic depression and involutional depression. The drug treats anxiety, depression, tension, sleep disturbances, worry, fear, sense of guilt and apprehension due to psychoneurosis. It is also prescribed for insomnia, pruritus and chronic idiopathic urticaria.

How to take Sinequan?
Sinequan recommended starting dose is 75 mg daily, administered as a single dose before bedtime or on a divided dosing schedule. Patients with mild symptomatology accompanying organic disease may be started at 25 mg or 50 mg daily. In severely ill patients the dose can be up titrated to 300 mg daily in divided dosage regimen. The maximum single dose shouldn’t exceed 150 mg. The drug exerts anti-anxiety effect more quickly than antidepressant one. It may require several weeks for the drug to exert an overt antidepressant effect.

When is Sinequan contraindicated?
Sinequan is contraindicated to patients with hyperthyroidism, glaucoma, brain tumors, respiratory impairments and a predisposition for developing urinary retention, for example due to prostatic hypertrophy. It is not recommended for use in pediatric population under 12 years of age.

What are Sinequan side effects?
Sinequan may provoke drowsiness, which generally improves as treatment continues. Other effects can be dizziness, confusion, increased sweating, dry mouth, weight gain, constipation and trouble urinating. If these symptoms do not subside with continued treatment, dosage reduction may be necessary. Gradual dose tapering after prolonged administration of the drug is required to avoid withdrawal symptoms.